Protein folding/misfolding initiation sites in GFP
Spring 2005
Proteins fold by forming local clusters of sidechains first, then by condensing or building on those clusters. The location(s) of the initial cluster formation can be hypothesized by looking for conserved sequence patterns or I-sites. Locations of misfolding sites can be hypothesized by looking for I-sites that do not match the crystal structure but instead match a non-native structure. We have found one such site in green fluorescent protein (GFP). Your project is to characterize point mutations in GFP that may change the balance of folded and misfolded initiation site. Prerequisites: lab skills, knowledge of molecular biology.
Protein Structure Prediction Web Site
Ongoing
Help building additional tools for the HMMSTR web server. You will become familier with HTML, Perl, and Csh scripts and the use of CGI interface. Currently we need display tools for aligned sequences, predicted structures, and better tools for navigating the I-sites Library. Add artwork! Prerequisites: Knowledge of the Unix environment.
Protein Design Workshop
Ongoing
Experiment in designing new proteins using MOE and in-house modeling tools. Prerequisites: Knowledge of the Unix environment, programming skill in any language.
Game development
Ongoing
ECOME is a model for an evolving food web. The Player chooses prey species and tries to stay alive as all species migrate and evolve. Help develop the front end of this game using graphical interface libraries such as OpenGL. Prerequisites: Knowledge of Fortran95 and basic concepts in GUI programming.
Thu Oct 4 08:49:43 EDT 2007