Common structures of the 5' non-coding RNA in enteroviruses and rhinoviruses. Thermodynamical stability and statistical significance.

Le SY; Zuker M

Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario.

J Mol Biol 216: 729-41 (1990)

Abstract
A total of 4051 suboptimal secondary structures are predicted by folding the 5' non-coding region of ten polioviruses, five human rhinoviruses and three coxsackieviruses using our new suboptimal folding algorithm for the prediction of both optimal and suboptimal RNA secondary structures. A comparative analysis of these RNA secondary structures reveals the conservation of common secondary structure that can be supported by phylogenetic data. The thermodynamic stability and statistical significance of these predicted, conserved helical elements are assessed and significant structure motifs in the 5' non-coding region are proposed. The possible roles of these structure motifs in the virus life cycle are discussed.

Mesh Headings

Base Sequence

Computer Simulation

Consensus Sequence

Coxsackieviruses

Enteroviruses*

Molecular Sequence Data

Nucleic Acid Conformation

Poliovirus

Rhinoviruses*

RNA, Viral*

Sequence Homology, Nucleic Acid

Statistics

Support, Non-U.S. Gov't

Thermodynamics

Unique Identifier: 91080160