Version 2.3 free energy parameters for RNA folding at 37°

  • Stacking energies
  • Terminal mismatch stacking energies (hairpin loops)
  • Terminal mismatch stacking energies (interior loops)
  • Single base stacking energies
  • Loop destabilizing energies
  • 1×1 loop energies
  • 2×2 loop energies
  • 1×2 loop energies
  • Tetra-loops
  • Tri-loops
  • Miscellaneous energies

    • Stacking energies at 37°:
    Data Arangement:                                                                                
                                                                                                
                 Y                                                                              
         ------------------                                                                     
     (X)  A    C    G    U                                                                      
         ------------------                                                                     
             5' ==> 3'                                                                          
                AX                                                                              
                AY                                                                              
             3' <== 5'                                                                          
     (A)   .     .     .     .                                                                  
     (C)   .     .     .     .                                                                  
     (G)   .     .     .     .                                                                  
     (U) -0.70 -0.10 -0.70 -0.10                                                                
                                                                                                
--------------------------------                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         AX                      AX                      AX                      AX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .     .     .     .     .     .     .     .   -0.90
   .     .     .     .     .     .     .     .     .     .     .     .     .     .   -2.10   .  
   .     .     .     .     .     .     .     .     .     .     .     .     .   -1.70   .   -0.50
   .     .     .     .     .     .     .     .     .     .     .     .   -0.90   .   -1.00   .  
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         CX                      CX                      CX                      CX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .     .     .     .   -1.80   .     .     .     .  
   .     .     .     .     .     .     .     .     .     .   -2.90   .     .     .     .     .  
   .     .     .     .     .     .     .     .     .   -2.00   .   -1.20   .     .     .     .  
   .     .     .     .     .     .     .     .   -1.70   .   -1.90   .     .     .     .     .  
                                                                                                
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         GX                      GX                      GX                      GX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .   -2.30   .     .     .     .     .     .     .   -1.10
   .     .     .     .     .     .   -3.40   .     .     .     .     .     .     .   -2.10   .  
   .     .     .     .     .   -2.90   .   -1.40   .     .     .     .     .   -1.90   .   -0.40
   .     .     .     .   -2.10   .   -2.10   .     .     .     .     .   -1.00   .    1.50   .  
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         UX                      UX                      UX                      UX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -1.10   .     .     .     .     .     .     .   -0.80   .     .     .     .  
   .     .   -2.30   .     .     .     .     .     .     .   -1.40   .     .     .     .     .  
   .   -1.80   .   -0.80   .     .     .     .     .   -1.20   .   -0.20   .     .     .     .  
 -0.90   .   -1.10   .     .     .     .     .   -0.50   .   -0.40   .     .     .     .     .

    Terminal mismatch stacking energies for hairpin loops at 37°:
    Data Arangement:                                                                                
                                                                                                
                 Y                                                                              
         ------------------                                                                     
     (X)  A    C    G    U                                                                      
         ------------------                                                                     
             5' ==> 3'                                                                          
                AX                                                                              
                AY                                                                              
             3' <== 5'                                                                          
     (A)   .     .     .     .                                                                  
     (C)   .     .     .     .                                                                  
     (G)   .     .     .     .                                                                  
     (U) -0.70 -0.10 -0.70 -0.10                                                                
                                                                                                
--------------------------------                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         AX                      AX                      AX                      AX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -1.00   .     .     .   -0.70   .     .     .   -1.80 -0.80 -1.00 -1.70 -1.00
   .     .   -1.10   .     .     .   -1.10   .     .     .   -2.30   .   -0.70 -0.70 -0.70 -0.70
   .   -1.40   .   -1.20   .   -1.00   .   -0.90   .   -2.10   .   -2.00 -1.50 -1.00 -1.00 -1.00
 -0.80   .   -0.80   .   -0.70   .   -0.70   .   -1.50   .   -1.50   .   -0.80 -0.80 -0.80 -0.80
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         CX                      CX                      CX                      CX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -0.80   .     .     .   -0.60 -1.40 -2.00 -2.10 -1.90   .     .     .   -0.60
   .     .   -1.30   .     .     .   -0.60   .   -1.00 -1.10 -1.00 -0.80   .     .   -0.80   .  
   .   -2.00   .   -1.40   .   -1.10   .   -0.90 -2.10 -1.90 -1.40 -1.90   .   -1.50   .   -1.10
 -1.00   .   -1.00   .   -0.70   .   -0.70   .   -1.40 -1.50 -1.40 -1.20 -0.80   .   -0.80   .  
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         GX                      GX                      GX                      GX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -1.80 -1.10 -1.30 -2.00 -1.30   .     .     .   -1.20 -0.80 -1.00 -1.70 -1.00
   .     .   -2.00   .   -1.10 -0.60 -0.60 -0.50   .     .   -1.40   .   -0.70 -0.70 -0.70 -0.70
   .   -2.10   .   -2.00 -2.30 -1.50 -1.40 -1.50   .   -1.40   .   -1.30 -1.50 -1.00 -1.00 -1.00
 -1.70   .   -1.70   .   -0.80 -0.80 -0.80 -0.70 -1.00   .   -1.00   .   -0.80 -0.80 -0.80 -0.80
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         UX                      UX                      UX                      UX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
 -1.00 -0.80 -1.80 -0.90   .     .     .   -0.50 -1.20 -1.40 -2.00 -1.40   .     .     .   -0.50
 -0.70 -0.60 -0.30 -0.50   .     .   -0.50   .   -0.90 -0.90 -0.70 -0.70   .     .   -0.70   .  
 -1.80 -0.90 -1.20 -0.90   .   -0.80   .   -0.70 -2.00 -1.40 -1.30 -1.40   .   -1.20   .   -0.90
 -0.30 -0.60 -0.30 -0.50 -0.70   .   -0.70   .   -0.90 -1.10 -0.90 -0.90 -0.80   .   -0.80   .

    Terminal mismatch stacking energies for interior loops at 37°:
    Data Arangement:                                                                                
                                                                                                
                 Y                                                                              
         ------------------                                                                     
     (X)  A    C    G    U                                                                      
         ------------------                                                                     
             5' ==> 3'                                                                          
                AX                                                                              
                AY                                                                              
             3' <== 5'                                                                          
     (A)   .     .     .     .                                                                  
     (C)   .     .     .     .                                                                  
     (G)   .     .     .     .                                                                  
     (U) -0.70 -0.10 -0.70 -0.10                                                                
                                                                                                
--------------------------------                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         AX                      AX                      AX                      AX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -1.00   .     .     .   -1.00   .     .     .   -2.20 -1.00 -1.00 -2.20 -0.50
   .     .   -1.50   .     .     .   -1.50   .     .     .   -2.70   .   -1.00 -1.00 -0.20 -1.00
   .   -1.50   .   -1.00   .   -1.50   .   -1.00   .   -2.70   .   -2.20 -2.20 -0.50 -1.00 -0.50
 -1.00   .   -1.50   .   -1.00   .   -1.50   .   -2.20   .   -2.70   .   -0.30 -1.00 -0.30 -2.00
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         CX                      CX                      CX                      CX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -1.00   .     .     .   -1.00 -1.50 -1.50 -2.70 -1.90   .     .     .   -1.00
   .     .   -1.50   .     .     .   -1.50   .   -1.50 -1.50 -1.00 -1.50   .     .   -1.50   .  
   .   -1.50   .   -1.00   .   -1.50   .   -1.00 -2.70 -1.90 -1.50 -1.90   .   -1.50   .   -1.00
 -1.00   .   -1.50   .   -1.00   .   -1.50   .   -1.40 -1.50 -1.40 -2.50 -1.00   .   -1.50   .  
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         GX                      GX                      GX                      GX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .   -2.20 -1.50 -1.50 -2.70 -1.30   .     .     .   -1.00 -1.50 -1.50 -2.70 -1.30
   .     .   -2.70   .   -1.50 -1.50 -0.60 -1.50   .     .   -1.50   .   -1.50 -1.50 -0.60 -1.50
   .   -2.70   .   -2.20 -2.70 -1.50 -1.50 -1.50   .   -1.50   .   -1.00 -2.70 -1.50 -1.50 -1.50
 -2.20   .   -2.70   .   -0.80 -1.50 -0.80 -2.50 -1.00   .   -1.50   .   -0.80 -1.50 -0.80 -2.50
                                                                                                
                                                                                                
          Y                       Y                       Y                       Y             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         UX                      UX                      UX                      UX             
         AY                      CY                      GY                      UY             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
 -1.00 -1.00 -2.20 -0.40   .     .     .   -1.00 -1.00 -1.00 -2.20 -0.40   .     .     .   -2.00
 -1.00 -1.00  0.20 -1.00   .     .   -1.50   .   -1.00 -1.00  0.20 -1.00   .     .   -2.50   .  
 -2.20 -0.40 -1.00 -0.40   .   -1.50   .   -1.00 -2.20 -0.40 -1.00 -0.40   .   -2.50   .   -2.00
  0.20 -1.00  0.20 -2.00 -1.00   .   -1.50   .    0.20 -1.00  0.20 -2.00 -2.00   .   -2.50   .

    Single base stacking energies at 37°:
              X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         AX                      AX                      AX                      AX             
         A                       C                       G                       U              
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .     .     .     .     .   -0.80 -0.50 -0.80 -0.60
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         CX                      CX                      CX                      CX             
         A                       C                       G                       U              
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .   -1.70 -0.80 -1.70 -1.20   .     .     .     .  
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         GX                      GX                      GX                      GX             
         A                       C                       G                       U              
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .   -1.10 -0.40 -1.30 -0.60   .     .     .     .   -0.80 -0.50 -0.80 -0.60
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         UX                      UX                      UX                      UX             
         A                       C                       G                       U              
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
 -0.70 -0.10 -0.70 -0.10   .     .     .     .   -1.20 -0.50 -1.20 -0.70   .     .     .     .  
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         A                       A                       A                       A              
         AX                      CX                      GX                      UX             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .     .     .     .     .   -0.30 -0.10 -0.20 -0.20
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         C                       C                       C                       C              
         AX                      CX                      GX                      UX             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .     .     .     .     .   -0.20 -0.30  0.00  0.00   .     .     .     .  
                                                                                                
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         G                       G                       G                       G              
         AX                      CX                      GX                      UX             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
   .     .     .     .   -0.50 -0.30 -0.20 -0.10   .     .     .     .   -0.20 -0.20 -0.20 -0.20
                                                                                                
                                                                                                
          X                       X                       X                       X             
  ------------------      ------------------      ------------------      ------------------    
   A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U     
  ------------------      ------------------      ------------------      ------------------    
      5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'         
         U                       U                       U                       U              
         AX                      CX                      GX                      UX             
      3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'         
 -0.30 -0.30 -0.40 -0.20   .     .     .     .   -0.20 -0.20 -0.20 -0.20   .     .     .     .

    Loop destabilizing energies at 37°:
    DESTABILIZING ENERGIES BY SIZE OF LOOP (INTERPOLATE WHERE NEEDED)     
hp3 ave calc no tmm;hp4 ave calc with tmm; ave all bulges             
SIZE         INTERNAL          BULGE            HAIRPIN               
-------------------------------------------------------               
 1               .                3.90              .  
 2              4.10              3.10              .  
 3              5.10              3.50             4.10
 4              4.90              4.20             4.90
 5              5.30              4.80             4.40
 6              5.70              5.00             4.70
 7              5.90              5.20             5.00
 8              6.00              5.30             5.10
 9              6.10              5.40             5.20
10              6.30              5.50             5.30
11              6.40              5.70             5.40
12              6.40              5.70             5.50
13              6.50              5.80             5.60
14              6.60              5.90             5.70
15              6.70              6.00             5.80
16              6.80              6.10             5.80
17              6.80              6.10             5.90
18              6.90              6.20             5.90
19              6.90              6.20             6.00
20              7.00              6.30             6.10
21              7.10              6.30             6.10
22              7.10              6.40             6.20
23              7.10              6.40             6.20
24              7.20              6.50             6.30
25              7.20              6.50             6.30
26              7.30              6.50             6.30
27              7.30              6.60             6.40
28              7.40              6.70             6.40
29              7.40              6.70             6.50
30              7.40              6.70             6.50

    Single mismatch (1×1 interior loop) energies at 37°:
    Data Arrangement:                                 
                                                  
            Y                                     
    ------------------                            
(X)  A    C    G    U                             
    ------------------                            
        5' --> 3'                                 
            X                                     
           A A                                    
           U U                                    
            Y                                     
        3' <-- 5'                                 
(A)  .    .    .    .                             
(C)  .    .    .    .                             
(G)  .    .    .    .                             
(U)  .    .    .    .                             
                                                                                                                                                
                                                                                                                                                
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           A A                     A C                     A G                     A U                     A G                     A U          
           U U                     U G                     U C                     U A                     U U                     U G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           C A                     C C                     C G                     C U                     C G                     C U          
           G U                     G G                     G C                     G A                     G U                     G G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G A                     G C                     G G                     G U                     G G                     G U          
           C U                     C G                     C C                     C A                     C U                     C G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U A                     U C                     U G                     U U                     U G                     U U          
           A U                     A G                     A C                     A A                     A U                     A G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G A                     G C                     G G                     G U                     G G                     G U          
           U U                     U G                     U C                     U A                     U U                     U G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U A                     U C                     U G                     U U                     U G                     U U          
           G U                     G G                     G C                     G A                     G U                     G G          
            Y                       Y                       Y                       Y                       Y                       Y           
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80
  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80  0.80

    Tandem mismatch (2×2 interior loop) energies at 37°:
    Data arrangement:                                                                               
                                                                                                
                                Y                                                               
     ----------------------------------------------------------------                           
(X)   A   A   A   A   C   C   C   C   G   G   G   G   U   U   U   U                             
      A   C   G   U   A   C   G   U   A   C   G   U   A   C   G   U                             
     ----------------------------------------------------------------                           
                           5' ------> 3'                                                        
                            A \/ \_/ A                                                          
                            U /\  |  U                                                          
                           3' <------ 5'                                                        
                                                                                                
(AA)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(AC)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(AG)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(AU)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(CA)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(CC)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(CG)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(CU)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(GA)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(GC)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(GG)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(GU)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(UA)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(UC)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(UG)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
(UU)  .   .   .   .   .   .   .   .   .   .   .   .   .   .   .   .                             
                                                                                                
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ A                                           
                                           U /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.70  3.70  2.50  4.90  3.70  3.70  4.30  3.70  2.50  4.90  3.70  4.90  4.30  3.70  4.30  2.70
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  3.60  3.60  2.40  4.80  3.60  3.60  4.20  3.60  2.40  4.80  3.60  4.80  4.20  3.60  4.20  2.60
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.60  3.60  2.40  4.80  3.60  3.60  4.20  3.60  2.40  4.80  3.60  4.80  4.20  3.60  4.20  2.60
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ C                                           
                                           U /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.20  3.20  2.00  3.90  3.20  3.20  3.20  3.20  2.00  4.10  3.20  3.90  3.40  3.20  3.20  2.20
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  3.10  3.10  1.90  3.80  3.10  3.10  3.10  3.10  1.90  4.00  3.10  3.80  3.30  3.10  3.10  2.10
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.10  3.10  1.90  4.00  3.10  3.80  3.30  3.10  3.10  2.10
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ G                                           
                                           U /\  |  C                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  2.90  2.90  1.70  3.00  2.90  2.90  2.50  2.90  1.70  3.40  2.90  3.00  2.50  2.90  2.50  1.90
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.20  3.20  2.00  3.30  3.20  3.20  2.80  3.20  2.00  3.70  3.20  3.30  2.80  3.20  2.80  2.20
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  2.90  2.90  1.70  3.00  2.90  2.90  2.50  2.90  1.70  3.40  2.90  3.00  2.50  2.90  2.50  1.90
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.90  2.90  1.70  3.00  2.90  2.90  2.50  2.90  1.70  3.40  2.90  3.00  2.50  2.90  2.50  1.90
  3.10  3.10  1.90  3.20  3.10  3.10  2.70  3.10  1.90  3.60  3.10  3.20  2.70  3.10  2.70  2.10
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.10  3.10  1.90  3.20  3.10  3.10  2.70  3.10  1.90  3.60  3.10  3.20  2.70  3.10  2.70  2.10
  1.40  1.40  0.20  1.50  1.40  1.40  1.00  1.40  0.20  1.90  1.40  1.50  1.00  1.40  1.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ U                                           
                                           U /\  |  A                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.40  3.40  2.20  4.10  3.40  3.40  3.90  3.40  2.20  4.20  3.40  4.10  3.90  3.40  3.90  2.40
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  3.70  3.70  2.50  4.40  3.70  3.70  4.20  3.70  2.50  4.50  3.70  4.40  4.20  3.70  4.20  2.70
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.40  3.40  2.20  4.10  3.40  3.40  3.90  3.40  2.20  4.20  3.40  4.10  3.90  3.40  3.90  2.40
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  3.40  3.40  2.20  4.10  3.40  3.40  3.90  3.40  2.20  4.20  3.40  4.10  3.90  3.40  3.90  2.40
  3.60  3.60  2.40  4.30  3.60  3.60  4.10  3.60  2.40  4.40  3.60  4.30  4.10  3.60  4.10  2.60
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  3.60  3.60  2.40  4.30  3.60  3.60  4.10  3.60  2.40  4.40  3.60  4.30  4.10  3.60  4.10  2.60
  1.90  1.90  0.70  2.60  1.90  1.90  2.40  1.90  0.70  2.70  1.90  2.60  2.40  1.90  2.40  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ G                                           
                                           U /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.70  3.70  2.50  4.90  3.70  3.70  4.30  3.70  2.50  4.90  3.70  4.90  4.30  3.70  4.30  2.70
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.40  3.40  2.20  4.60  3.40  3.40  4.00  3.40  2.20  4.60  3.40  4.60  4.00  3.40  4.00  2.40
  3.60  3.60  2.40  4.80  3.60  3.60  4.20  3.60  2.40  4.80  3.60  4.80  4.20  3.60  4.20  2.60
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.60  3.60  2.40  4.80  3.60  3.60  4.20  3.60  2.40  4.80  3.60  4.80  4.20  3.60  4.20  2.60
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           A \/ \_/ U                                           
                                           U /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.20  3.20  2.00  3.90  3.20  3.20  3.20  3.20  2.00  4.10  3.20  3.90  3.40  3.20  3.20  2.20
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.90  2.90  1.70  3.60  2.90  2.90  2.90  2.90  1.70  3.80  2.90  3.60  3.10  2.90  2.90  1.90
  3.10  3.10  1.90  3.80  3.10  3.10  3.10  3.10  1.90  4.00  3.10  3.80  3.30  3.10  3.10  2.10
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.10  3.10  1.90  4.00  3.10  3.80  3.30  3.10  3.10  2.10
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ A                                           
                                           G /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.50  2.50  1.30  3.70  2.50  2.50  3.10  2.50  1.30  3.70  2.50  3.70  3.10  2.50  3.10  1.50
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.50  2.50  1.30  3.70  2.50  2.50  3.10  2.50  1.30  3.70  2.50  3.70  3.10  2.50  3.10  1.50
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ C                                           
                                           G /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  2.00  2.00  0.80  2.70  2.00  2.00  2.00  2.00  0.80  2.90  2.00  2.70  2.20  2.00  2.00  1.00
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.00  2.00  0.80  2.70  2.00  2.00  2.00  2.00  0.80  2.90  2.00  2.70  2.20  2.00  2.00  1.00
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ G                                           
                                           G /\  |  C                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  1.50  1.50  0.30  1.60  1.50  1.50  1.10  1.50  0.30  2.00  1.50  1.60  1.10  1.50  1.10  0.50
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  1.50  1.50  0.30  1.60  1.50  1.50  1.10  1.50  0.30  2.00  1.50  1.60  1.10  1.50  1.10  0.50
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.50  1.50  0.30  1.60  1.50  1.50  1.10  1.50  0.30  2.00  1.50  1.60  1.10  1.50  1.10  0.50
  2.00  2.00  0.80  2.10  2.00  2.00  1.60  2.00  0.80  2.50  2.00  2.10  1.60  2.00  1.60  1.00
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.00  2.00  0.80  2.10  2.00  2.00  1.60  2.00  0.80  2.50  2.00  2.10  1.60  2.00  1.60  1.00
  0.90  0.90 -0.30  1.00  0.90  0.90  0.50  0.90 -0.30  1.40  0.90  1.00  0.50  0.90  0.50 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ U                                           
                                           G /\  |  A                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.00  2.00  0.80  2.70  2.00  2.00  2.50  2.00  0.80  2.80  2.00  2.70  2.50  2.00  2.50  1.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.00  2.00  0.80  2.70  2.00  2.00  2.50  2.00  0.80  2.80  2.00  2.70  2.50  2.00  2.50  1.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.00  2.00  0.80  2.70  2.00  2.00  2.50  2.00  0.80  2.80  2.00  2.70  2.50  2.00  2.50  1.00
  2.50  2.50  1.30  3.20  2.50  2.50  3.00  2.50  1.30  3.30  2.50  3.20  3.00  2.50  3.00  1.50
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.50  2.50  1.30  3.20  2.50  2.50  3.00  2.50  1.30  3.30  2.50  3.20  3.00  2.50  3.00  1.50
  1.40  1.40  0.20  2.10  1.40  1.40  1.90  1.40  0.20  2.20  1.40  2.10  1.90  1.40  1.90  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ G                                           
                                           G /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.00  2.00  0.80  3.20  2.00  2.00  2.60  2.00  0.80  3.20  2.00  3.20  2.60  2.00  2.60  1.00
  2.50  2.50  1.30  3.70  2.50  2.50  3.10  2.50  1.30  3.70  2.50  3.70  3.10  2.50  3.10  1.50
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.50  2.50  1.30  3.70  2.50  2.50  3.10  2.50  1.30  3.70  2.50  3.70  3.10  2.50  3.10  1.50
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           C \/ \_/ U                                           
                                           G /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.50  1.50  0.30  2.20  1.50  1.50  1.50  1.50  0.30  2.40  1.50  2.20  1.70  1.50  1.50  0.50
  2.00  2.00  0.80  2.70  2.00  2.00  2.00  2.00  0.80  2.90  2.00  2.70  2.20  2.00  2.00  1.00
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.00  2.00  0.80  2.70  2.00  2.00  2.00  2.00  0.80  2.90  2.00  2.70  2.20  2.00  2.00  1.00
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ A                                           
                                           C /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.60  2.60  1.40  3.80  2.60  2.60  3.20  2.60  1.40  3.80  2.60  3.80  3.20  2.60  3.20  1.60
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.30  3.30  2.10  4.50  3.30  3.30  3.90  3.30  2.10  4.50  3.30  4.50  3.90  3.30  3.90  2.30
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ C                                           
                                           C /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  2.10  2.10  0.90  2.80  2.10  2.10  2.10  2.10  0.90  3.00  2.10  2.80  2.30  2.10  2.10  1.10
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.80  2.80  1.60  3.50  2.80  2.80  2.80  2.80  1.60  3.70  2.80  3.50  3.00  2.80  2.80  1.80
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ G                                           
                                           C /\  |  C                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  2.10  2.10  0.90  2.20  2.10  2.10  1.70  2.10  0.90  2.60  2.10  2.20  1.70  2.10  1.70  1.10
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.80  2.80  1.60  2.90  2.80  2.80  2.40  2.80  1.60  3.30  2.80  2.90  2.40  2.80  2.40  1.80
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.60  2.60  1.40  2.70  2.60  2.60  2.20  2.60  1.40  3.10  2.60  2.70  2.20  2.60  2.20  1.60
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.60  2.60  1.40  2.70  2.60  2.60  2.20  2.60  1.40  3.10  2.60  2.70  2.20  2.60  2.20  1.60
  0.90  0.90 -0.30  1.00  0.90  0.90  0.50  0.90 -0.30  1.40  0.90  1.00  0.50  0.90  0.50 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ U                                           
                                           C /\  |  A                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.60  2.60  1.40  3.30  2.60  2.60  3.10  2.60  1.40  3.40  2.60  3.30  3.10  2.60  3.10  1.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.30  3.30  2.10  4.00  3.30  3.30  3.80  3.30  2.10  4.10  3.30  4.00  3.80  3.30  3.80  2.30
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.60  3.10  1.90  3.90  3.10  3.80  3.60  3.10  3.60  2.10
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.60  3.10  1.90  3.90  3.10  3.80  3.60  3.10  3.60  2.10
  1.40  1.40  0.20  2.10  1.40  1.40  1.90  1.40  0.20  2.20  1.40  2.10  1.90  1.40  1.90  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ G                                           
                                           C /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.60  2.60  1.40  3.80  2.60  2.60  3.20  2.60  1.40  3.80  2.60  3.80  3.20  2.60  3.20  1.60
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.30  3.30  2.10  4.50  3.30  3.30  3.90  3.30  2.10  4.50  3.30  4.50  3.90  3.30  3.90  2.30
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ U                                           
                                           C /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  2.10  2.10  0.90  2.80  2.10  2.10  2.10  2.10  0.90  3.00  2.10  2.80  2.30  2.10  2.10  1.10
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.80  2.80  1.60  3.50  2.80  2.80  2.80  2.80  1.60  3.70  2.80  3.50  3.00  2.80  2.80  1.80
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ A                                           
                                           A /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ C                                           
                                           A /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ G                                           
                                           A /\  |  C                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  1.40  1.40  0.20  1.50  1.40  1.40  1.00  1.40  0.20  1.90  1.40  1.50  1.00  1.40  1.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ U                                           
                                           A /\  |  A                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  1.90  1.90  0.70  2.60  1.90  1.90  2.40  1.90  0.70  2.70  1.90  2.60  2.40  1.90  2.40  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ G                                           
                                           A /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ U                                           
                                           A /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ A                                           
                                           U /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.60  2.60  1.40  3.80  2.60  2.60  3.20  2.60  1.40  3.80  2.60  3.80  3.20  2.60  3.20  1.60
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.30  3.30  2.10  4.50  3.30  3.30  3.90  3.30  2.10  4.50  3.30  4.50  3.90  3.30  3.90  2.30
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ C                                           
                                           U /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  2.10  2.10  0.90  2.80  2.10  2.10  2.10  2.10  0.90  3.00  2.10  2.80  2.30  2.10  2.10  1.10
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.80  2.80  1.60  3.50  2.80  2.80  2.80  2.80  1.60  3.70  2.80  3.50  3.00  2.80  2.80  1.80
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ G                                           
                                           U /\  |  C                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  2.10  2.10  0.90  2.20  2.10  2.10  1.70  2.10  0.90  2.60  2.10  2.20  1.70  2.10  1.70  1.10
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.80  2.80  1.60  2.90  2.80  2.80  2.40  2.80  1.60  3.30  2.80  2.90  2.40  2.80  2.40  1.80
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  0.70  0.70 -0.50  0.80  0.70  0.70  0.30  0.70 -0.50  1.20  0.70  0.80  0.30  0.70  0.30 -0.30
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.60  2.60  1.40  2.70  2.60  2.60  2.20  2.60  1.40  3.10  2.60  2.70  2.20  2.60  2.20  1.60
  1.90  1.90  0.70  2.00  1.90  1.90  1.50  1.90  0.70  2.40  1.90  2.00  1.50  1.90  1.50  0.90
  2.60  2.60  1.40  2.70  2.60  2.60  2.20  2.60  1.40  3.10  2.60  2.70  2.20  2.60  2.20  1.60
  0.90  0.90 -0.30  1.00  0.90  0.90  0.50  0.90 -0.30  1.40  0.90  1.00  0.50  0.90  0.50 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ U                                           
                                           U /\  |  A                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.60  2.60  1.40  3.30  2.60  2.60  3.10  2.60  1.40  3.40  2.60  3.30  3.10  2.60  3.10  1.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.30  3.30  2.10  4.00  3.30  3.30  3.80  3.30  2.10  4.10  3.30  4.00  3.80  3.30  3.80  2.30
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.70  1.20  0.00  2.00  1.20  1.90  1.70  1.20  1.70  0.20
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.60  3.10  1.90  3.90  3.10  3.80  3.60  3.10  3.60  2.10
  2.40  2.40  1.20  3.10  2.40  2.40  2.90  2.40  1.20  3.20  2.40  3.10  2.90  2.40  2.90  1.40
  3.10  3.10  1.90  3.80  3.10  3.10  3.60  3.10  1.90  3.90  3.10  3.80  3.60  3.10  3.60  2.10
  1.40  1.40  0.20  2.10  1.40  1.40  1.90  1.40  0.20  2.20  1.40  2.10  1.90  1.40  1.90  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ G                                           
                                           U /\  |  U                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.60  2.60  1.40  3.80  2.60  2.60  3.20  2.60  1.40  3.80  2.60  3.80  3.20  2.60  3.20  1.60
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.30  3.30  2.10  4.50  3.30  3.30  3.90  3.30  2.10  4.50  3.30  4.50  3.90  3.30  3.90  2.30
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  1.20  1.20  0.00  2.40  1.20  1.20  1.80  1.20  0.00  2.40  1.20  2.40  1.80  1.20  1.80  0.20
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  2.40  2.40  1.20  3.60  2.40  2.40  3.00  2.40  1.20  3.60  2.40  3.60  3.00  2.40  3.00  1.40
  3.10  3.10  1.90  4.30  3.10  3.10  3.70  3.10  1.90  4.30  3.10  4.30  3.70  3.10  3.70  2.10
  1.40  1.40  0.20  2.60  1.40  1.40  2.00  1.40  0.20  2.60  1.40  2.60  2.00  1.40  2.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           G \/ \_/ U                                           
                                           U /\  |  G                                           
                                          3' <------ 5'                                         
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  2.10  2.10  0.90  2.80  2.10  2.10  2.10  2.10  0.90  3.00  2.10  2.80  2.30  2.10  2.10  1.10
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.80  2.80  1.60  3.50  2.80  2.80  2.80  2.80  1.60  3.70  2.80  3.50  3.00  2.80  2.80  1.80
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  0.70  0.70 -0.50  1.40  0.70  0.70  0.70  0.70 -0.50  1.60  0.70  1.40  0.90  0.70  0.70 -0.30
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  1.90  1.90  0.70  2.60  1.90  1.90  1.90  1.90  0.70  2.80  1.90  2.60  2.10  1.90  1.90  0.90
  2.60  2.60  1.40  3.30  2.60  2.60  2.60  2.60  1.40  3.50  2.60  3.30  2.80  2.60  2.60  1.60
  0.90  0.90 -0.30  1.60  0.90  0.90  0.90  0.90 -0.30  1.80  0.90  1.60  1.10  0.90  0.90 -0.10
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ A                                           
                                           G /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ C                                           
                                           G /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ G                                           
                                           G /\  |  C                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  1.20  1.20  0.00  1.30  1.20  1.20  0.80  1.20  0.00  1.70  1.20  1.30  0.80  1.20  0.80  0.20
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.00  3.00  1.80  3.10  3.00  3.00  2.60  3.00  1.80  3.50  3.00  3.10  2.60  3.00  2.60  2.00
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  2.40  2.40  1.20  2.50  2.40  2.40  2.00  2.40  1.20  2.90  2.40  2.50  2.00  2.40  2.00  1.40
  3.60  3.60  2.40  3.70  3.60  3.60  3.20  3.60  2.40  4.10  3.60  3.70  3.20  3.60  3.20  2.60
  1.40  1.40  0.20  1.50  1.40  1.40  1.00  1.40  0.20  1.90  1.40  1.50  1.00  1.40  1.00  0.40
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ U                                           
                                           G /\  |  A                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  1.70  1.70  0.50  2.40  1.70  1.70  2.20  1.70  0.50  2.50  1.70  2.40  2.20  1.70  2.20  0.70
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  3.50  3.50  2.30  4.20  3.50  3.50  4.00  3.50  2.30  4.30  3.50  4.20  4.00  3.50  4.00  2.50
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  2.90  2.90  1.70  3.60  2.90  2.90  3.40  2.90  1.70  3.70  2.90  3.60  3.40  2.90  3.40  1.90
  4.10  4.10  2.90  4.80  4.10  4.10  4.60  4.10  2.90  4.90  4.10  4.80  4.60  4.10  4.60  3.10
  1.90  1.90  0.70  2.60  1.90  1.90  2.40  1.90  0.70  2.70  1.90  2.60  2.40  1.90  2.40  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ G                                           
                                           G /\  |  U                                           
                                          3' <------ 5'                                         
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  1.70  1.70  0.50  2.90  1.70  1.70  2.30  1.70  0.50  2.90  1.70  2.90  2.30  1.70  2.30  0.70
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  3.50  3.50  2.30  4.70  3.50  3.50  4.10  3.50  2.30  4.70  3.50  4.70  4.10  3.50  4.10  2.50
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  2.90  2.90  1.70  4.10  2.90  2.90  3.50  2.90  1.70  4.10  2.90  4.10  3.50  2.90  3.50  1.90
  4.10  4.10  2.90  5.30  4.10  4.10  4.70  4.10  2.90  5.30  4.10  5.30  4.70  4.10  4.70  3.10
  1.90  1.90  0.70  3.10  1.90  1.90  2.50  1.90  0.70  3.10  1.90  3.10  2.50  1.90  2.50  0.90
                                                                                                
                                               Y                                                
   ---------------------------------------------------------------------------------------------
    A     A     A     A     C     C     C     C     G     G     G     G     U     U     U     U 
    A     C     G     U     A     C     G     U     A     C     G     U     A     C     G     U 
   ---------------------------------------------------------------------------------------------
                                          5' ------> 3'                                         
                                           U \/ \_/ U                                           
                                           G /\  |  G                                           
                                          3' <------ 5'                                         
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  1.20  1.20  0.00  1.90  1.20  1.20  1.20  1.20  0.00  2.10  1.20  1.90  1.40  1.20  1.20  0.20
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.00  3.00  1.80  3.70  3.00  3.00  3.00  3.00  1.80  3.90  3.00  3.70  3.20  3.00  3.00  2.00
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  2.40  2.40  1.20  3.10  2.40  2.40  2.40  2.40  1.20  3.30  2.40  3.10  2.60  2.40  2.40  1.40
  3.60  3.60  2.40  4.30  3.60  3.60  3.60  3.60  2.40  4.50  3.60  4.30  3.80  3.60  3.60  2.60
  1.40  1.40  0.20  2.10  1.40  1.40  1.40  1.40  0.20  2.30  1.40  2.10  1.60  1.40  1.40  0.40

    Asymmetric 1×2 interior loop energies at 37°:
    Data arrangement:                                                     
                                                                      
            Y                                                         
    ------------------                                                
(X)  A    C    G    U                                                 
    ------------------                                                
        5' --> 3'                                                     
            X                                                         
           A  A                                                       
           U  U                                                       
            YA                                                        
        3' <-- 5'                                                     
(A)  .    .    .    .                                                 
(C)  .    .    .    .                                                 
(G)  .    .    .    .                                                 
(U)  .    .    .    .                                                 
                                                                                                                                                
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           A  A                    A  C                    A  G                    A  U                    A  G                    A  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  3.90  2.90  2.90  1.70  3.40  2.90  2.90  1.70  3.40  3.40  3.40  2.20  3.90  3.40  3.40  2.20  3.90  2.90  2.90  1.70  3.40
  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90  2.90  2.90  3.70  2.90  3.40  3.40  4.20  3.40  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90
  1.00  2.70  2.20  2.70  0.50  2.20  1.70  2.20  0.50  2.20  1.70  2.20  1.00  2.70  2.20  2.70  1.00  2.70  2.20  2.70  0.50  2.20  1.70  2.20
  4.70  4.00  4.70  3.00  3.80  3.10  3.80  2.10  3.20  2.50  3.20  1.50  4.60  3.90  4.60  2.90  4.70  4.00  4.70  3.00  3.80  3.10  3.80  2.10
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           A  A                    A  C                    A  G                    A  U                    A  G                    A  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  3.90  2.90  2.90  1.70  3.40  2.90  2.90  1.70  3.40  3.40  3.40  2.20  3.90  3.40  3.40  2.20  3.90  2.90  2.90  1.70  3.40
  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90  2.90  2.90  3.70  2.90  3.40  3.40  4.20  3.40  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90
  3.40  5.10  4.60  5.10  2.60  4.30  3.80  4.30  2.20  3.90  3.40  3.90  3.00  4.70  4.20  4.70  3.40  5.10  4.60  5.10  2.60  4.30  3.80  4.30
  4.10  3.40  4.10  2.40  3.60  2.90  3.60  1.90  3.60  2.90  3.60  1.90  4.10  3.40  4.10  2.40  4.10  3.40  4.10  2.40  3.60  2.90  3.60  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           A  A                    A  C                    A  G                    A  U                    A  G                    A  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.20  2.20  1.00  2.70  1.70  1.70  0.50  2.20  1.70  1.70  0.50  2.20  2.20  2.20  1.00  2.70  2.20  2.20  1.00  2.70  1.70  1.70  0.50  2.20
  4.00  4.00  4.80  4.00  2.90  2.90  3.70  2.90  2.50  2.50  3.30  2.50  3.90  3.90  4.70  3.90  4.00  4.00  4.80  4.00  2.90  2.90  3.70  2.90
  2.20  3.90  3.40  3.90  1.70  3.40  2.90  3.40  1.70  3.40  2.90  3.40  2.20  3.90  3.40  3.90  2.20  3.90  3.40  3.90  1.70  3.40  2.90  3.40
  4.70  4.00  4.70  3.00  3.60  2.90  3.60  1.90  3.20  2.50  3.20  1.50  4.60  3.90  4.60  2.90  4.70  4.00  4.70  3.00  3.60  2.90  3.60  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           A  A                    A  C                    A  G                    A  U                    A  G                    A  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.60  4.60  3.40  5.10  3.60  3.60  2.40  4.10  3.00  3.00  1.80  3.50  4.10  4.10  2.90  4.60  4.60  4.60  3.40  5.10  3.60  3.60  2.40  4.10
  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90  2.90  2.90  3.70  2.90  3.40  3.40  4.20  3.40  3.40  3.40  4.20  3.40  2.90  2.90  3.70  2.90
  3.40  5.10  4.60  5.10  2.40  4.10  3.60  4.10  1.80  3.50  3.00  3.50  2.90  4.60  4.10  4.60  3.40  5.10  4.60  5.10  2.40  4.10  3.60  4.10
  3.10  2.40  3.10  1.40  2.60  1.90  2.60  0.90  2.60  1.90  2.60  0.90  3.10  2.40  3.10  1.40  3.10  2.40  3.10  1.40  2.60  1.90  2.60  0.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           C  A                    C  C                    C  G                    C  U                    C  G                    C  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00  2.40  2.40  1.20  2.00  2.90  2.90  1.70  2.50  2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00
  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40  2.40  2.40  2.90  2.40  2.90  2.90  3.40  2.90  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40
  0.50  1.30  1.70  1.30  0.00  0.80  1.20  0.80  0.00  0.80  1.20  0.80  0.50  1.30  1.70  1.30  0.50  1.30  1.70  1.30  0.00  0.80  1.20  0.80
  3.60  3.50  3.60  2.50  2.70  2.60  2.70  1.60  2.10  2.00  2.10  1.00  3.50  3.40  3.50  2.40  3.60  3.50  3.60  2.50  2.70  2.60  2.70  1.60
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           C  A                    C  C                    C  G                    C  U                    C  G                    C  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00  2.40  2.40  1.20  2.00  2.90  2.90  1.70  2.50  2.90  2.90  1.70  2.50  2.40  2.40  1.20  2.00
  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40  2.40  2.40  2.90  2.40  2.90  2.90  3.40  2.90  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40
  2.90  3.70  4.10  3.70  2.10  2.90  3.30  2.90  1.70  2.50  2.90  2.50  2.50  3.30  3.70  3.30  2.90  3.70  4.10  3.70  2.10  2.90  3.30  2.90
  3.00  2.90  3.00  1.90  2.50  2.40  2.50  1.40  2.50  2.40  2.50  1.40  3.00  2.90  3.00  1.90  3.00  2.90  3.00  1.90  2.50  2.40  2.50  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           C  A                    C  C                    C  G                    C  U                    C  G                    C  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  1.70  1.70  0.50  1.30  1.20  1.20  0.00  0.80  1.20  1.20  0.00  0.80  1.70  1.70  0.50  1.30  1.70  1.70  0.50  1.30  1.20  1.20  0.00  0.80
  3.50  3.50  4.00  3.50  2.40  2.40  2.90  2.40  2.00  2.00  2.50  2.00  3.40  3.40  3.90  3.40  3.50  3.50  4.00  3.50  2.40  2.40  2.90  2.40
  1.70  2.50  2.90  2.50  1.20  2.00  2.40  2.00  1.20  2.00  2.40  2.00  1.70  2.50  2.90  2.50  1.70  2.50  2.90  2.50  1.20  2.00  2.40  2.00
  3.60  3.50  3.60  2.50  2.50  2.40  2.50  1.40  2.10  2.00  2.10  1.00  3.50  3.40  3.50  2.40  3.60  3.50  3.60  2.50  2.50  2.40  2.50  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           C  A                    C  C                    C  G                    C  U                    C  G                    C  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.10  4.10  2.90  3.70  3.10  3.10  1.90  2.70  2.50  2.50  1.30  2.10  3.60  3.60  2.40  3.20  4.10  4.10  2.90  3.70  3.10  3.10  1.90  2.70
  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40  2.40  2.40  2.90  2.40  2.90  2.90  3.40  2.90  2.90  2.90  3.40  2.90  2.40  2.40  2.90  2.40
  2.90  3.70  4.10  3.70  1.90  2.70  3.10  2.70  1.30  2.10  2.50  2.10  2.40  3.20  3.60  3.20  2.90  3.70  4.10  3.70  1.90  2.70  3.10  2.70
  2.00  1.90  2.00  0.90  1.50  1.40  1.50  0.40  1.50  1.40  1.50  0.40  2.00  1.90  2.00  0.90  2.00  1.90  2.00  0.90  1.50  1.40  1.50  0.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           C  U                    C  G                    C  C                    C  A                    C  U                    C  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20  0.00  1.20  1.20  1.20  0.50  1.70  1.70  1.70  0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20
  4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           C  U                    C  G                    C  C                    C  A                    C  U                    C  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30  1.70  2.90  2.90  2.90  2.50  3.70  3.70  3.70  2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30
  3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40  3.10  2.40  3.10  1.40  3.60  2.90  3.60  1.90  3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           C  U                    C  G                    C  C                    C  A                    C  U                    C  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40  1.20  1.20  0.00  1.40  1.70  1.70  0.50  1.90  1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40
  3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40  2.00  2.00  2.90  2.00  3.40  3.40  4.30  3.40  3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40
  1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40  1.20  2.40  2.40  2.40  1.70  2.90  2.90  2.90  1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40
  4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           C  U                    C  G                    C  C                    C  A                    C  U                    C  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.10  4.10  2.90  4.30  3.10  3.10  1.90  3.30  2.50  2.50  1.30  2.70  3.60  3.60  2.40  3.80  4.10  4.10  2.90  4.30  3.10  3.10  1.90  3.30
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  2.90  4.10  4.10  4.10  1.90  3.10  3.10  3.10  1.30  2.50  2.50  2.50  2.40  3.60  3.60  3.60  2.90  4.10  4.10  4.10  1.90  3.10  3.10  3.10
  2.60  1.90  2.60  0.90  2.10  1.40  2.10  0.40  2.10  1.40  2.10  0.40  2.60  1.90  2.60  0.90  2.60  1.90  2.60  0.90  2.10  1.40  2.10  0.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           A  U                    A  G                    A  C                    A  A                    A  U                    A  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50  2.90  2.90  1.70  3.50  3.40  3.40  2.20  4.00  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  1.00  2.80  2.20  2.80  0.50  2.30  1.70  2.30  0.50  2.30  1.70  2.30  1.00  2.80  2.20  2.80  1.00  2.80  2.20  2.80  0.50  2.30  1.70  2.30
  5.20  4.00  5.20  3.00  4.30  3.10  4.30  2.10  3.70  2.50  3.70  1.50  5.10  3.90  5.10  2.90  5.20  4.00  5.20  3.00  4.30  3.10  4.30  2.10
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           A  U                    A  G                    A  C                    A  A                    A  U                    A  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50  2.90  2.90  1.70  3.50  3.40  3.40  2.20  4.00  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  3.40  5.20  4.60  5.20  2.60  4.40  3.80  4.40  2.20  4.00  3.40  4.00  3.00  4.80  4.20  4.80  3.40  5.20  4.60  5.20  2.60  4.40  3.80  4.40
  4.60  3.40  4.60  2.40  4.10  2.90  4.10  1.90  4.10  2.90  4.10  1.90  4.60  3.40  4.60  2.40  4.60  3.40  4.60  2.40  4.10  2.90  4.10  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           A  U                    A  G                    A  C                    A  A                    A  U                    A  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.20  2.20  1.00  2.80  1.70  1.70  0.50  2.30  1.70  1.70  0.50  2.30  2.20  2.20  1.00  2.80  2.20  2.20  1.00  2.80  1.70  1.70  0.50  2.30
  4.00  4.00  5.20  4.00  2.90  2.90  4.10  2.90  2.50  2.50  3.70  2.50  3.90  3.90  5.10  3.90  4.00  4.00  5.20  4.00  2.90  2.90  4.10  2.90
  2.20  4.00  3.40  4.00  1.70  3.50  2.90  3.50  1.70  3.50  2.90  3.50  2.20  4.00  3.40  4.00  2.20  4.00  3.40  4.00  1.70  3.50  2.90  3.50
  5.20  4.00  5.20  3.00  4.10  2.90  4.10  1.90  3.70  2.50  3.70  1.50  5.10  3.90  5.10  2.90  5.20  4.00  5.20  3.00  4.10  2.90  4.10  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           A  U                    A  G                    A  C                    A  A                    A  U                    A  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.60  4.60  3.40  5.20  3.60  3.60  2.40  4.20  3.00  3.00  1.80  3.60  4.10  4.10  2.90  4.70  4.60  4.60  3.40  5.20  3.60  3.60  2.40  4.20
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  3.40  5.20  4.60  5.20  2.40  4.20  3.60  4.20  1.80  3.60  3.00  3.60  2.90  4.70  4.10  4.70  3.40  5.20  4.60  5.20  2.40  4.20  3.60  4.20
  3.60  2.40  3.60  1.40  3.10  1.90  3.10  0.90  3.10  1.90  3.10  0.90  3.60  2.40  3.60  1.40  3.60  2.40  3.60  1.40  3.10  1.90  3.10  0.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20  0.00  1.20  1.20  1.20  0.50  1.70  1.70  1.70  0.50  1.70  1.70  1.70  0.00  1.20  1.20  1.20
  4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.30  2.60  3.30  1.60
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60  2.40  2.40  1.20  2.60  2.90  2.90  1.70  3.10  2.90  2.90  1.70  3.10  2.40  2.40  1.20  2.60
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30  1.70  2.90  2.90  2.90  2.50  3.70  3.70  3.70  2.90  4.10  4.10  4.10  2.10  3.30  3.30  3.30
  3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40  3.10  2.40  3.10  1.40  3.60  2.90  3.60  1.90  3.60  2.90  3.60  1.90  3.10  2.40  3.10  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40  1.20  1.20  0.00  1.40  1.70  1.70  0.50  1.90  1.70  1.70  0.50  1.90  1.20  1.20  0.00  1.40
  3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40  2.00  2.00  2.90  2.00  3.40  3.40  4.30  3.40  3.50  3.50  4.40  3.50  2.40  2.40  3.30  2.40
  1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40  1.20  2.40  2.40  2.40  1.70  2.90  2.90  2.90  1.70  2.90  2.90  2.90  1.20  2.40  2.40  2.40
  4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40  2.70  2.00  2.70  1.00  4.10  3.40  4.10  2.40  4.20  3.50  4.20  2.50  3.10  2.40  3.10  1.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           G  A                    G  C                    G  G                    G  U                    G  G                    G  U         
           U  U                    U  G                    U  C                    U  A                    U  U                    U  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.10  4.10  2.90  4.30  3.10  3.10  1.90  3.30  2.50  2.50  1.30  2.70  3.60  3.60  2.40  3.80  4.10  4.10  2.90  4.30  3.10  3.10  1.90  3.30
  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40  2.40  2.40  3.30  2.40  2.90  2.90  3.80  2.90  2.90  2.90  3.80  2.90  2.40  2.40  3.30  2.40
  2.90  4.10  4.10  4.10  1.90  3.10  3.10  3.10  1.30  2.50  2.50  2.50  2.40  3.60  3.60  3.60  2.90  4.10  4.10  4.10  1.90  3.10  3.10  3.10
  2.60  1.90  2.60  0.90  2.10  1.40  2.10  0.40  2.10  1.40  2.10  0.40  2.60  1.90  2.60  0.90  2.60  1.90  2.60  0.90  2.10  1.40  2.10  0.40
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YA                      YA                      YA                      YA                      YA                      YA          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50  2.90  2.90  1.70  3.50  3.40  3.40  2.20  4.00  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  1.00  2.80  2.20  2.80  0.50  2.30  1.70  2.30  0.50  2.30  1.70  2.30  1.00  2.80  2.20  2.80  1.00  2.80  2.20  2.80  0.50  2.30  1.70  2.30
  5.20  4.00  5.20  3.00  4.30  3.10  4.30  2.10  3.70  2.50  3.70  1.50  5.10  3.90  5.10  2.90  5.20  4.00  5.20  3.00  4.30  3.10  4.30  2.10
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YC                      YC                      YC                      YC                      YC                      YC          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50  2.90  2.90  1.70  3.50  3.40  3.40  2.20  4.00  3.40  3.40  2.20  4.00  2.90  2.90  1.70  3.50
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  3.40  5.20  4.60  5.20  2.60  4.40  3.80  4.40  2.20  4.00  3.40  4.00  3.00  4.80  4.20  4.80  3.40  5.20  4.60  5.20  2.60  4.40  3.80  4.40
  4.60  3.40  4.60  2.40  4.10  2.90  4.10  1.90  4.10  2.90  4.10  1.90  4.60  3.40  4.60  2.40  4.60  3.40  4.60  2.40  4.10  2.90  4.10  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YG                      YG                      YG                      YG                      YG                      YG          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  2.20  2.20  1.00  2.80  1.70  1.70  0.50  2.30  1.70  1.70  0.50  2.30  2.20  2.20  1.00  2.80  2.20  2.20  1.00  2.80  1.70  1.70  0.50  2.30
  4.00  4.00  5.20  4.00  2.90  2.90  4.10  2.90  2.50  2.50  3.70  2.50  3.90  3.90  5.10  3.90  4.00  4.00  5.20  4.00  2.90  2.90  4.10  2.90
  2.20  4.00  3.40  4.00  1.70  3.50  2.90  3.50  1.70  3.50  2.90  3.50  2.20  4.00  3.40  4.00  2.20  4.00  3.40  4.00  1.70  3.50  2.90  3.50
  5.20  4.00  5.20  3.00  4.10  2.90  4.10  1.90  3.70  2.50  3.70  1.50  5.10  3.90  5.10  2.90  5.20  4.00  5.20  3.00  4.10  2.90  4.10  1.90
                                                                                                                                                
            Y                       Y                       Y                       Y                       Y                       Y           
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
     A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U        A    C    G    U   
    ------------------      ------------------      ------------------      ------------------      ------------------      ------------------  
        5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'               5' --> 3'       
            X                       X                       X                       X                       X                       X           
           U  A                    U  C                    U  G                    U  U                    U  G                    U  U         
           G  U                    G  G                    G  C                    G  A                    G  U                    G  G         
            YU                      YU                      YU                      YU                      YU                      YU          
        3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'               3' <-- 5'       
  4.60  4.60  3.40  5.20  3.60  3.60  2.40  4.20  3.00  3.00  1.80  3.60  4.10  4.10  2.90  4.70  4.60  4.60  3.40  5.20  3.60  3.60  2.40  4.20
  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90  2.90  2.90  4.10  2.90  3.40  3.40  4.60  3.40  3.40  3.40  4.60  3.40  2.90  2.90  4.10  2.90
  3.40  5.20  4.60  5.20  2.40  4.20  3.60  4.20  1.80  3.60  3.00  3.60  2.90  4.70  4.10  4.70  3.40  5.20  4.60  5.20  2.40  4.20  3.60  4.20
  3.60  2.40  3.60  1.40  3.10  1.90  3.10  0.90  3.10  1.90  3.10  0.90  3.60  2.40  3.60  1.40  3.60  2.40  3.60  1.40  3.10  1.90  3.10  0.90

    Tetra-loop bonus energies at 37°:
     Seq  Energy   
 -----------   
 AGAAAU  -2.00
 AGCAAU  -2.00
 AGAGAU  -2.00
 AGUGAU  -2.00
 AGGAAU  -2.00
 AUUCGU  -2.00
 AUACGU  -2.00
 AGCGAU  -2.00
 AUCCGU  -2.00
 AGUAAU  -2.00
 ACUUGU  -2.00
 AAUUUU  -2.00
 AUUUAU  -2.00
 CGAAAG  -2.00
 CGCAAG  -2.00
 CGAGAG  -2.00
 CGUGAG  -2.00
 CGGAAG  -2.00
 CUUCGG  -2.00
 CUACGG  -2.00
 CGCGAG  -2.00
 CUCCGG  -2.00
 CGUAAG  -2.00
 CCUUGG  -2.00
 CAUUUG  -2.00
 CUUUAG  -2.00
 GGAAAC  -2.00
 GGCAAC  -2.00
 GGAGAC  -2.00
 GGUGAC  -2.00
 GGGAAC  -2.00
 GUUCGC  -2.00
 GUACGC  -2.00
 GGCGAC  -2.00
 GUCCGC  -2.00
 GGUAAC  -2.00
 GCUUGC  -2.00
 GAUUUC  -2.00
 GUUUAC  -2.00
 UGAAAA  -2.00
 UGCAAA  -2.00
 UGAGAA  -2.00
 UGUGAA  -2.00
 UGGAAA  -2.00
 UUUCGA  -2.00
 UUACGA  -2.00
 UGCGAA  -2.00
 UUCCGA  -2.00
 UGUAAA  -2.00
 UCUUGA  -2.00
 UAUUUA  -2.00
 UUUUAA  -2.00
 GGAAAU  -2.00
 GGCAAU  -2.00
 GGAGAU  -2.00
 GGUGAU  -2.00
 GGGAAU  -2.00
 GUUCGU  -2.00
 GUACGU  -2.00
 GGCGAU  -2.00
 GUCCGU  -2.00
 GGUAAU  -2.00
 GCUUGU  -2.00
 GAUUUU  -2.00
 GUUUAU  -2.00
 UGAAAG  -2.00
 UGCAAG  -2.00
 UGAGAG  -2.00
 UGUGAG  -2.00
 UGGAAG  -2.00
 UUUCGG  -2.00
 UUACGG  -2.00
 UGCGAG  -2.00
 UUCCGG  -2.00
 UGUAAG  -2.00
 UCUUGG  -2.00
 UAUUUG  -2.00
 UUUUAG  -2.00

    Tri-loop bonus energies at 37°:
     Seq    Energy 
 -------------

    Miscellaneous energies at 37°:
    FREE ENERGY BY SIZE OF LOOP                                             
misc. loop functions                                                    
--> internal, bulge or hairpin loops > 30: dS(T)=dS(30)+param*ln(n/30)  
 1.079
asymmetric internal loops: the ninio equation                           
--> the maximum correction                                              
  3.00
--> the f(m) array (see ninio for details)                              
  0.30  0.30  0.30  0.30
multibranched loops                                                     
--> offset,  free base penalty,  helix penalty                          
      4.60         0.40              0.10
                                                                        
efn2 multibranched loops                                                
   offset,  free base penalty,  helix penalty                           
-->                                                                     
     10.10        -0.30             -0.30
                                                                        
terminal AU penalty                                                     
-->                                                                     
  0.00
                                                                        
bonus for GGG hairpin                                                   
-->                                                                     
  0.00
                                                                        
c hairpin slope                                                         
-->                                                                     
  0.00
                                                                        
c hairpin intercept                                                     
-->                                                                     
  0.00
                                                                        
c hairpin of 3                                                          
-->                                                                     
  0.00
                                                                        
Intermolecular initiation free energy                                   
-->                                                                     
  4.10
                                                                        
GAIL Rule (Grossly Asymmetric Interior Loop Rule) (on/off <-> 1/0)      
-->                                                                     
0