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Systems under investigation include the growth and development of
neurons on surfaces with micrometer scale topography. Implantable
devices to restore brain function lost to disease or trauma. Biosensors
for the detection of cells and molecules are also being developed.
The other major component of Dr. Turner's research involves the application
of three-dimensional light microscopy, especially confocal microscopy,
to the study of the three-dimensional structure of biological specimens.
This includes collaborative efforts with Dr. Barinath Roysam of the
Rensselaer Polytechnic Institute to develop automated image analysis
tools.
Main publications in Nanobiotechnology:
• Lowe CR. Nanobiotechnology:
the fabrication and applications of chemical and biological nanostructures.
Current Opinion in Structural Biology. 2000 Aug;10(4):428-34.
Publications of general
interest:
• Laval JM, Mazeran PE, Thomas
D. Nanobiotechnology and its role in the development of new analytical
devices. Analyst. 2000 Jan;125(1):29-33.
Dr. Turner's publications
in Image Processing:
• Becker,
D. E., Can, A., Tanenbaum, H. L., and Turner, J. N., Roysam, B.,
"Image Processing Algorithms for Retinal Montage Synthesis,
Mapping, and Real-Time Location Determination," IMIA Yearbook
of Medical Informatics, International Medical Informatics Association,
Schattauer Press, Germany, (Bemmel et al., eds), pp. 433-446, 1999.
(Selected by the International Medical Informatics Association as
one of four papers in image analysis for reprinting is a special
volume)
• Al-Kofahi, K, Lasek, S, Szarowski,
DH, Pace, C, Nagy, G, Turner, JN, Roysam, B: Rapid automated three-dimensional
tracing of neurons from confocal image stacks. IEEE Trans. Information
Theory in Biomedicine. 6, 171-187, 2002.
Dr. Turner's publications
in Nanotechnology:
•
Russo, A.P., Apoga, D., Dowell, N., Shain, W. Turner, A., Craighead,
H., Hoch, H.C., and Turner, J.N. Microfabricated Plastic Devices
from Silicon Using Soft Intermediates. Biomedical Microdevices, 4,
277-283, 2002.
•
Kam, L, Shain, W, Turner, J.N., Bizios, R Selective Adhesion of
Astrocytes to Surfaces Modified with Immobilized Peptides, Biomaterials,
23, 511-515, 2002.
•
Kam, L., Shain, W., Turner, J.N., and Bizios, R., "Axonal
Outgrowth of Hippocampal Neurons on Micro-Scale Networks of Polylysine-Conjugated
Laminin, Biomaterials, 22, 1049-105, 2001.
•
Shen, H., Roysam, B., Stewart, C., Turner, J.N., And Tanenbaum,
H., Optimal Scheduling of Tracing Computations for Real-time Vascular
Landmark Extraction from Retinal Images. IEEE Trans. Biomed. 5,
77-91, 2001.
•
Perez, A., Dowell, N., Kam, L., Turner, S., Craighead, H.G., Isaacson,
M., Turner, J.N. And Shain, W. Attachment of Astroglial Cells to
Photolithographically Patterned and Chemically Etched Pillar Arrays
of Different Geometries. J. Biomedical Materials Res., 51, 430-441,
2000.
•
James, C.D., Davis, R.C., Meyer, M., Perez, A., Turner, S., Withers,
G., Kam, L., Banker, G., Craighead, H.G., Isaacson, M., Turner,
J.N., And Shain, W. Aligned Microcontact Printing of Micrometer
Scale Polylysine Structures for Controlled Growth of Cultured Neurons
on Planar Microelectrode Arrays. IEEE Trans. Biomed. Eng., 47,
17-21, 2000.
•
Kam, L., Shain, W., Turner, J.N., And Bizios, R. Correlation of
Astroglial Cell Function on Micro-Patterned Surfaces with Specific
Geometric Parameters. Biomaterials, 20, 2343-2350, 1999.
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Researcher