Selected publications from CatSper Project team members
   Chris Bystroff
   Jean-Ju Chung
   Scott Forth
   Aileen Gariepy
   Jon Hennebold
   Scott Michael & Sharon Isern
   Clair Kaplan
   Rajesh Naz
   William Ryerson
   Fred Sigworth
   Chunyu Wang
   Robert Wyman
Bibliography for selected topics
   Sperm motility may be inhibited by antibodies.
   Contraceptive vaccines work in many animal models and human.
   Gardasil vaccine is highly immunogenic for up to four years.
   Chimeric VLPs raise immunity against inserted peptides.
   There is a strong demand for LARCs.
   Providing charismatic role models in entertainment influences sexual behavior.
    Demographic Projections
    Unwanted Pregnancy
    Infant and Child Mortality
   Sterilization
    Contraceptive Market and Pricing
    Population and Economic Development
    Overshoot

Selected publications from CatSper Project team members

Chris Bystroff

1: Huang YM, Banerjee S, Crone DE, Schenkelberg CD, Pitman DJ, Buck PM, Bystroff C. Toward Computationally Designed Self-Reporting Biosensors Using Leave-One-Out Green Fluorescent Protein. Biochemistry. 2015 Oct 13;54(40):6263-73. doi: 10.1021/acs.biochem.5b00786. Epub 2015 Sep 30. PMID: 26397806

2: Pitman DJ, Banerjee S, Macari SJ, Castaldi CA, Crone DE, Bystroff C. Exploring the folding pathway of green fluorescent protein through disulfide engineering. Protein Sci. 2015 Mar;24(3):341-53. doi: 10.1002/pro.2621. Epub 2015 Jan 13. PMID: 25516354

3: Bystroff C. Human Population, BIOL 4961, Spring 2016, Rensselaer Polytechnic Institute, 4 credits.

Jean-Ju Chung

4: Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE. Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility. Cell. 2014 May 8;157(4):808-22. doi: 10.1016/j.cell.2014.02.056. PubMed PMID: 24813608; PubMed Central PMCID: PMC4032590.

5: Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Nat Commun. 2011 Jan 11;2:153. PubMed PMID: 21224844; PubMed Central PMCID: PMC3999383.

6: Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annu Rev Physiol. 2012;74:453-75. doi: 10.1146/annurev-physiol-020911-153258. Epub 2011 Oct 13. Review. PubMed PMID: 22017176; PubMed Central PMCID: PMC3914660.

Scott Forth

7: Forth S, Hsia KC, Shimamoto Y, Kapoor TM. Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks. Cell. 2014 Apr 10;157(2):420-32. doi: 10.1016/j.cell.2014.02.018. PubMed PMID: 24725408; PubMed Central PMCID: PMC4015189.

8: Shimamoto Y, Forth S, Kapoor TM. Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules. Dev Cell. 2015 Sep 28;34(6):669-81. doi: 10.1016/j.devcel.2015.08.017. PubMed PMID: 26418296; PubMed Central PMCID: PMC4604754.

9: Ti SC, Pamula MC, Howes SC, Duellberg C, Cade NI, Kleiner RE, Forth S, Surrey T, Nogales E, Kapoor TM. Mutations in Human Tubulin Proximal to the Kinesin Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Dev Cell. 2016 Apr 4;37(1):72-84. doi: 10.1016/j.devcel.2016.03.003. PubMed PMID: 27046833; PubMed Central PMCID: PMC4832424.

Aileen Gariepy

10: Lundsberg LS, Pal L, Gariepy AM, Xu X, Chu MC, Illuzzi JL. Knowledge, attitudes, and practices regarding conception and fertility: a population-based survey among reproductive-age United States women. Fertil Steril. 2014 Mar;101(3):767-74. doi: 10.1016/j.fertnstert.2013.12.006. Epub 2014 Jan 30. PubMed PMID: 24484995.

11: Gressel GM, Lundsberg LS, Illuzzi JL, Danton CM, Sheth SS, Xu X, Gariepy A. Patient and provider perspectives on Bedsider.org, an online contraceptive information tool, in a low income, racially diverse clinic population. Contraception. 2014 Dec;90(6):588-93. doi: 10.1016/j.contraception.2014.07.010. Epub 2014 Jul 25. PubMed PMID: 25139723.

12: Dhruva SS, Ross JS, Gariepy AM. Revisiting Essure--Toward Safe and Effective Sterilization. N Engl J Med. 2015 Oct 8;373(15):e17. doi: 10.1056/NEJMp1510514. Epub 2015 Sep 23. PubMed PMID: 26397951.

Jon Hennebold

13: Murphy MJ, Halow NG, Royer PA, Hennebold JD. Leukemia Inhibitory Factor is Necessary for Ovulation in Female Rhesus Macaques. Endocrinology. 2016 Aug 29:en20161283. [Epub ahead of print] PubMed PMID: 27571132.

14: Bishop CV, Xu F, Molskness TA, Stouffer RL, Hennebold JD. Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone. Biol Reprod. 2015 Nov;93(5):112. doi: 10.1095/biolreprod.115.132753. Epub 2015 Sep 23. PubMed PMID: 26400401.

15: Peluffo MC, Stanley J, Braeuer N, Rotgeri A, Fritzemeier KH, Fuhrmann U, Buchmann B, Adevai T, Murphy MJ, Zelinski MB, Lindenthal B, Hennebold JD, Stouffer RL. A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques. Hum Reprod. 2014 Jul;29(7):1400-12. Epub 2014 Apr 29. PubMed PMID: 24781425; PubMed Central PMCID: PMC4059334.

Scott Michael & Sharon Isern

16: Costin JM, Zaitseva E, Kahle KM, Nicholson CO, Rowe DK, Graham AS, Bazzone LE, Hogancamp G, Figueroa Sierra M, Fong RH, Yang ST, Lin L, Robinson JE, Doranz BJ, Chernomordik LV, Michael SF, Schieffelin JS, Isern S. Mechanistic study of broadly neutralizing human monoclonal antibodies against dengue virus that target the fusion loop. J Virol. 2013 Jan;87(1):52-66. doi: 10.1128/JVI.02273-12. Epub 2012 Oct 17. PubMed PMID: 23077306; PubMed Central PMCID: PMC3536401.

17: Nicholson CO, Costin JM, Rowe DK, Lin L, Jenwitheesuk E, Samudrala R, Isern S, Michael SF. Viral entry inhibitors block dengue antibody-dependent enhancement in vitro. Antiviral Res. 2011 Jan;89(1):71-4. doi: 10.1016/j.antiviral.2010.11.008. Epub 2010 Nov 18. PubMed PMID: 21093488.

18: Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. Structural optimization and de novo design of dengue virus entry inhibitory peptides. PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721. doi: 10.1371/journal.pntd.0000721. PubMed PMID: 20582308; PubMed Central PMCID: PMC2889824.

Clair Kaplan

19: Klisz C, Kaplan C. HPV prevention update. New vaccine offers additional options. Adv Nurse Pract. 2009 Nov;17(11):28-9, 54. PubMed PMID: 20014688.

20: Kaplan C. Intrauterine contraception. Considerations for special populations...and more. Adv Nurse Pract. 2007 Nov;15(11):47-8, 50-2. Review. PubMed PMID: 19998914.

21: Raymond EG, Weaver MA, Louie KS, Tan YL, Bousiéguez M, Aranguré-Peraza AG, Lugo-Hernández EM, Sanhueza P, Goldberg AB, Culwell KR, Kaplan C, Memmel L, Sonalkar S, Jamshidi R, Winikoff B. Effects of Depot Medroxyprogesterone Acetate Injection Timing on Medical Abortion Efficacy and Repeat Pregnancy: A Randomized Controlled Trial. Obstet Gynecol. 2016 Sep 5. [Epub ahead of print] PubMed PMID: 27607859.

Rajesh Naz

22: Naz RK, Saver AE. Immunocontraception for Animals: Current Status and Future Perspective. Am J Reprod Immunol. 2016 Apr;75(4):426-39. doi: 10.1111/aji.12431. Epub 2015 Sep 28. Review. PubMed PMID: 26412331.

23: Naz RK. Recent progress toward development of vaccines against conception. Expert Rev Vaccines. 2014 Jan;13(1):145-54. doi: 10.1586/14760584.2014.869420. Epub 2013 Dec 6. Review. PubMed PMID: 24308631.

24: Naz RK. Female genital tract immunity: distinct immunological challenges for vaccine development. J Reprod Immunol. 2012 Jan;93(1):1-8. doi: 10.1016/j.jri.2011.09.005. Epub 2011 Dec 10. Review. PubMed PMID: 22154945.

William Ryerson

25: Ryerson WN. Family planning: looking beyond access. Science. 2011 Mar 11;331(6022):1265; PMID: 21393528

26: Ryerson, William N. "The effectiveness of entertainment mass media in changing behavior." Population Media Center (2008).

27: Ryerson, William N. "Population: The multiplier of everything else." The Post Carbon Reader: Managing the 21st Centurys Sustainability Crises (2010): 153-75.

Fred Sigworth

28: Singh SK, Sigworth FJ. Cryo-EM: Spinning the Micelles Away. Structure. 2015 Sep 1;23(9):1561. doi: 10.1016/j.str.2015.08.001. PubMed PMID: 26331455; PubMed Central PMCID: PMC4901521.

29: Liu Y, Sigworth FJ. Automatic cryo-EM particle selection for membrane proteins in spherical liposomes. J Struct Biol. 2014 Mar;185(3):295-302. doi: 10.1016/j.jsb.2014.01.004. Epub 2014 Jan 24. PubMed PMID: 24468290; PubMed Central PMCID: PMC3978669.

30: Kucukelbir A, Sigworth FJ, Tagare HD. Quantifying the local resolution of cryo-EM density maps. Nat Methods. 2014 Jan;11(1):63-5. doi: 10.1038/nmeth.2727. Epub 2013 Nov 10. PubMed PMID: 24213166; PubMed Central PMCID: PMC3903095.

Chunyu Wang

31: Chen W, Gamache E, Rosenman DJ, Xie J, Lopez MM, Li YM, Wang C. Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site. Nat Commun. 2014;5:3037. doi: 10.1038/ncomms4037. PubMed PMID: 24390130; PubMed Central PMCID: PMC4082030.

32: Xie J, Du Z, Callahan B, Belfort M, Wang C. ¹H, ¹³C and ¹⁵N NMR assignments of a Drosophila Hedgehog autoprocessing domain. Biomol NMR Assign. 2014 Oct;8(2):279-81. doi: 10.1007/s12104-013-9500-8. Epub 2013 Jun 14. PubMed PMID: 23765287; PubMed Central PMCID: PMC3884045.

33: Du Z, Liu J, Albracht CD, Hsu A, Chen W, Marieni MD, Colelli KM, Williams JE, Reitter JN, Mills KV, Wang C. Structural and mutational studies of a hyperthermophilic intein from DNA polymerase II of Pyrococcus abyssi. J Biol Chem. 2011 Nov 4;286(44):38638-48. doi: 10.1074/jbc.M111.290569. Epub 2011 Sep 13. PubMed PMID: 21914805; PubMed Central PMCID: PMC3207444.

Robert Wyman

34: Wyman, Robert (2013) Population pressure and Global Warming in the Depletion of Fresh Water. Population and Development Review (39):687-704.

35: Yao, Guigui and Wyman, R .J. (2016) Population pp 304-315 In: Routledge Handbook of Religion and Ecology. Willis Jenkins, Mary Evelyn Tucker and John Grim, Eds. Routledge, Taylor and Francis, London.

36: Wyman, RJ. MCDB 150: GLOBAL PROBLEMS OF POPULATION GROWTH. Open Yale Courses.

Bibliography for selected topics

Sperm motility may be inhibited by antibodies.

37: Barratt CL, Havelock LM, Harrison PE, Cooke ID. Antisperm antibodies are more prevalent in men with low sperm motility. Int J Androl. 1989 Apr;12(2):110-16.PubMed PMID: 2722270.

38: O'Rand MG, Widgren EE, Beyler S, Richardson RT. Inhibition of human sperm motility by contraceptive anti-eppin antibodies from infertile male monkeys: effect on cyclic adenosine monophosphate. Bill Reprod. 2009 Feb;80(2):279-85. doi: 10.1095/biolreprod.108.072942. Epub 2008 Oct 22. PubMed PMID: 18945989; PubMed Central PMCID: PMC2630362.

39: Kornovski BS, McCoshen J, Kredentser J, Turley E. The regulation of sperm motility by a novel hyaluronan receptor. Fertil Steril. 1994 May;61(5):935-40. PubMed PMID: 7513657.

40: Li, Honggang, Xiaofang Ding, Huangtao Guan, and Chengliang Xiong. "Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region." Fertility and sterility 92, no. 3 (2009): 1141-1146.

41: Li, Honggang, Xiaofang Ding, Cuicui Guo, Huangtao Guan, and Chengliang Xiong. "Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility." Fertility and sterility 97, no. 2 (2012): 445-452.

Contraceptive vaccines work in many animal models and human.

42: Han M, Yao Y, Zeng W, Wang Y, Feng L, Zhao J. Complexes of trophoblastic peptides and heat shock protein 70 as a novel contraceptive vaccine in a mouse model. Reprod Biomed Online. 2016 Apr;32(4):457-65. doi:10.1016/j.rbmo.2015.12.009. Epub 2016 Jan 15. PubMed PMID: 26847794.

43: Xue F, Wang L, Liu Y, Tang H, Xu W, Xu C. Vaccination with an Epitope Peptide of IZUMO1 to Induce Contraception in Female Mice. Am J Reprod Immunol. 2016 Apr;75(4):474-85. doi: 10.1111/aji.12485. Epub 2016 Jan 19. PubMed PMID:26782177.

44: Joonè CJ, Bertschinger HJ, Gupta SK, Fosgate GT, Arukha AP, Minhas V, Dieterman E, Schulman ML. Ovarian function and pregnancy outcome in pony mares following immunocontraception with native and recombinant porcine zona pellucid vaccines. Equine Vet J. 2015 Dec 26. doi: 10.1111/evj.12557. [Epub ahead of print] PubMed PMID: 26708619.

45: Caldeira J, Bustos J, Peabody J, Chackerian B, Peabody DS. Epitope-Specific Anti-hCG Vaccines on a Virus Like Particle Platform. PLoS One. 2015 Oct 30;10(10):e0141407. doi: 10.1371/journal.pone.0141407. eCollection 2015. PubMed PMID: 26516771; PubMed Central PMCID: PMC4627648.

46: Benka VA, Levy JK. Vaccines for feline contraception: GonaCon GnRH-hemocyanin conjugate immunocontraceptive. J Feline Med Surg. 2015 Sep;17(9):758-65. doi:10.1177/1098612X15594989. Review. PubMed PMID: 26323799.

47: Marti S, Devant M, Amatayakul-Chantler S, Jackson JA, Lopez E, Janzen ED, Schwartzkopf-Genswein KS. Effect of anti-gonadotropin-releasing factor vaccine and band castration on indicators of welfare in beef cattle. J Anim Sci. 2015 Apr;93(4):1581-91. doi: 10.2527/jas.2014-8346. PubMed PMID: 26020180.

48: Yu Q, Mei XQ, Ding XF, Dong TT, Dong WW, Li HG. Construction of a catsper1 DNA vaccine and its antifertility effect on male mice. PLoS One. 2015 May 18;10(5):e0127508. doi: 10.1371/journal.pone.0127508. eCollection 2015. PubMed PMID: 25993432; PubMed Central PMCID: PMC4436331.

49: Mask TA, Schoenecker KA, Kane AJ, Ransom JI, Bruemmer JE. Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination. Theriogenology. 2015 Jul 15;84(2):261-7. doi: 10.1016/j.theriogenology.2015.03.012. Epub 2015 Mar 24. PubMed PMID:25922172.

50: Dalmau A, Velarde A, Rodríguez P, Pedernera C, Llonch P, Fàbrega E, Casal N,Mainau E, Gispert M, King V, Slootmans N, Thomas A, Mombarg M. Use of an anti-GnRF vaccine to suppress estrus in crossbred Iberian female pigs. Theriogenology. 2015 Aug;84(3):342-7. doi: 10.1016/j.theriogenology 2015.03.025. Epub 2015 Mar 28. PubMed PMID: 25908572.

51: Zhou B, Wang P, Zhang K, Jin FS, Li YF, Zhang J, Sun ZY. Reduction of fertility in male mice immunised with pSG.SS.C3d3.YL.Bin1b recombinant vaccine. Eur J Contracept Reprod Health Care. 2015;20(5):372-8. doi: 10.3109/13625187.2015.1021771. Epub 2015 Mar 17. PubMed PMID: 25784400.

52: Han Y, Liu G, Jiang X, Ijaz N, Tesema B, Xie G. KISS1 can be used as a novel target for developing a DNA immunocastration vaccine in ram lambs. Vaccine. 2015 Feb 4;33(6):777-82. doi: 10.1016/j.vaccine.2014.12.054. Epub 2015 Jan 4. PubMed PMID: 25562792.

53: Shrestha A, Srichandan S, Minhas V, Panda AK, Gupta SK. Canine zona pellucid glycoprotein-3: up-scaled production, immunization strategy and its outcome on fertility. Vaccine. 2015 Jan 1;33(1):133-40. doi: 10.1016 j.vaccine.2014.11.003. Epub 2014 Nov 13. PubMed PMID: 25448113.

54: Chen Z, Shen Z, Li J, He W, Yang Y, Liang Z. Nasal immunization using a mimovirus vaccine based on the Eppin B-cell epitope induced suppressed fertility in mice. Hum Vaccin Immunother. 2014;10(8):2227-34. doi: 10.4161/hv.29200. PubMed PMID: 25424926; PubMed Central PMCID: PMC4896763.

55: Naz RK. Vaccine for human contraception targeting sperm Izumo protein and YLP12 dodecamer peptide. Protein Sci. 2014 Jul;23(7):857-68. doi: 10.1002/pro.2476. Epub 2014 Apr 22. Review. PubMed PMID: 24723387; PubMed Central PMCID: PMC4088970.

56: Xu C, Li YC, Yang H, Long Y, Chen MJ, Qin YF, Xia YK, Song L, Gu AH, Wang XR. The preparation and application of N-terminal 57 amino acid protein of the follicle-stimulating hormone receptor as a candidate male contraceptive vaccine. Asian J Androl. 2014 Jul-Aug;16(4):623-30. doi: 10.4103/1008-682X.125910. PubMed PMID: 24713829; PubMed Central PMCID: PMC4104094.

57: Asmus MD, Tavarez MA, Tokach MD, Dritz SS, Schroeder AL, Nelssen JL, Goodband RD, DeRouchey JM. The effects of immunological castration and corn dried distillers grains with solubles withdrawal on growth performance, carcass characteristics, fatty acid analysis, and iodine value of pork fat depots. J Anim Sci. 2014 May;92(5):2116-32. doi: 10.2527/jas.2013-6910. Epub 2014 Mar 25. PubMed PMID: 24668958.

58: Puls CL, Rojo A, Ellis M, Boler DD, McKeith FK, Killefer J, Gaines AM, Matzat PD, Schroeder AL. Growth performance of immunologically castrated (with Improvest) barrows (with or without ractopamine) compared to gilt, physically castrated barrow, and intact male pigs. J Anim Sci. 2014 May;92(5):2289-95. doi:10.2527/jas.2013-6861. Epub 2014 Mar 26. PubMed PMID: 24671576.

Gardasil vaccine is highly immunogenic for up to four years.

59: Brown DR, Garland SM, Ferris DG, Joura E, Steben M, James M, Radley D, Vuocolo S, Garner EI, Haupt RM, Bryan JT. The humoral response to Gardasil over four years as defined by total IgG and competitive Luminex immunoassay. Hum Vaccin. 2011 Feb;7(2):230-8. Epub 2011 Feb 1. PubMed PMID: 21307649.

60: Villa LL, Costa RL, Petta CA, Andrade RP, Paavonen J, Iversen OE, Olsson SE,Høye J, Steinwall M, Riis-Johannessen G, Andersson-Ellstrom A, Elfgren K, Krogh Gv, Lehtinen M, Malm C, Tamms GM, Giacoletti K, Lupinacci L, Railkar R, Taddeo FJ, Bryan J, Esser MT, Sings HL, Saah AJ, Barr E. High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up. Br J Cancer. 2006 Dec 4;95(11):1459-66. Epub 2006 Nov 21. PubMed PMID: 17117182; PubMed Central PMCID:

61: GlaxoSmithKline Vaccine HPV-007 Study Group, Romanowski B, de Borba PC, Naud PS, Roteli-Martins CM, De Carvalho NS, Teixeira JC, Aoki F, Ramjattan B, Shier RM, Somani R, Barbier S, Blatter MM, Chambers C, Ferris D, Gall SA, Guerra FA, Harper DM, Hedrick JA, Henry DC, Korn AP, Kroll R, Moscicki AB, Rosenfeld WD,Sullivan BJ, Thoming CS, Tyring SK, Wheeler CM, Dubin G, Schuind A, Zahaf T,Greenacre M, Sgriobhadair A. Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomized placebo-controlled trial up to 6.4 years. Lancet. 2009 Dec 12;374(9706):1975-85. doi: 10.1016/S0140-6736(09)61567-1. Epub . PubMed PMID: 19962185.

62: FUTURE I/II Study Group, Dillner J, Kjaer SK, Wheeler CM, Sigurdsson K, Iversen OE, Hernandez-Avila M, Perez G, Brown DR, Koutsky LA, Tay EH, García P,Ault KA, Garland SM, Leodolter S, Olsson SE, Tang GW, Ferris DG, Paavonen J,Lehtinen M, Steben M, Bosch FX, Joura EA, Majewski S, Muñoz N, Myers ER, Villa LL, Taddeo FJ, Roberts C, Tadesse A, Bryan JT, Maansson R, Lu S, Vuocolo S,Hesley TM, Barr E, Haupt R. Four year efficacy of prophylactic human papilloma virus quadrivalent vaccine against low grade cervical, vulvar, and vaginal intraepithelial neoplasia and anogenital warts: randomised controlled trial. BMJ. 2010 Jul 20;341:c3493. doi: 10.1136/bmj.c3493. PubMed PMID: 20647284;PubMed Central PMCID: PMC2907480.

Chimeric VLPs raise immunity against inserted peptides.

63: Chu X, Li Y, Long Q, Xia Y, Yao Y, Sun W, Huang W, Yang X, Liu C, Ma Y. Chimeric HBcAg virus-like particles presenting a HPV 16 E7 epitope significantly suppressed tumor progression through preventive or therapeutic immunization in a TC-1-grafted mouse model. Int J Nanomedicine. 2016 May 27;11:2417-29. doi:10.2147/IJN.S102467. eCollection 2016. PubMed PMID: 27313455; PubMed Central PMCID: PMC4892837.

64: Hassani-Mehraban A, Creutzburg S, van Heereveld L, Kormelink R. Feasibility of Cowpea chlorotic mottle virus-like particles as scaffold for epitope presentations. BMC Biotechnol. 2015 Aug 27;15:80. doi: 10.1186/s12896-015-0180-6.PubMed PMID: 26311254; PubMed Central PMCID: PMC4551372.

65: Greenstone HL, Nieland JD, de Visser KE, De Bruijn ML, Kirnbauer R, Roden RB, Lowy DR, Kast WM, Schiller JT. Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1800-5. PubMed PMID: 9465097; PubMed Central PMCID: PMC19193.

66: Denis J, Acosta-Ramirez E, Zhao Y, Hamelin ME, Koukavica I, Baz M, Abed Y, Savard C, Pare C, Lopez Macias C, Boivin G, Leclerc D. Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform. Vaccine. 2008 Jun 25;26(27-28):3395-403. doi: 10.1016/j.vaccine.2008.04.052. Epub 2008 May 12. PubMed PMID: 18511159.

There is a strong demand for LARCs.

67: Neukom J, Chilambwe J, Mkandawire J, Mbewe RK, Hubacher D. Dedicated providers of long-acting reversible contraception: new approach in Zambia. Contraception.2011 May;83(5):447-52. doi: 10.1016/j.contraception.2010.08.021. Epub 2010 Oct 8.PubMed PMID: 21477688.

68: Blumenthal PD, Shah NM, Jain K, Saunders A, Clemente C, Lucas B, Jafa K, Eber M. Revitalizing long-acting reversible contraceptives in settings with high unmet need: a multicountry experience matching demand creation and service delivery.Contraception. 2013 Feb;87(2):170-5. doi: 10.1016/j.contraception.2012.10.002. Epub 2012 Nov 12. PubMed PMID: 23153895.

69: White K, Teal SB, Potter JE. Contraception after delivery and short interpregnancy intervals among women in the United States. Obstet Gynecol. 2015Jun;125(6):1471-7. doi: 10.1097/AOG.0000000000000841. PubMed PMID: 26000519;PubMed Central PMCID: PMC4443868.

70: McCoy SI, Buzdugan R, Ralph LJ, Mushavi A, Mahomva A, Hakobyan A, Watadzaushe C, Dirawo J, Cowan FM, Padian NS. Unmet need for family planning, contraceptive failure, and unintended pregnancy among HIV-infected and HIV-uninfected women in Zimbabwe. PLoS One. 2014 Aug 21;9(8):e105320. doi: 10.1371/journal.pone.0105320. eCollection 2014. PubMed PMID: 25144229; PubMed Central PMCID: PMC4140753.

Providing charismatic role models in entertainment influences sexual behavior.

71: Gibson, Donald E., and Diana I. Cordova. "Women's and men's role models: The importance of exemplars." Mentoring dilemmas: Developmental relationships within multicultural organizations (1999): 121-141.

72:Eaton, Liberty, Alan J. Flisher, and Leif E. Aaro. "Unsafe sexual behaviour in South African youth." Social science & medicine 56.1 (2003): 149-165.

73:Ward, L. Monique, and Rocio Rivadeneyra. "Contributions of entertainment television to adolescents sexual attitudes and expectations: The role of viewing amount versus viewer involvement." Journal of sex research 36.3 (1999): 237-249.

74:Rogers, Everett M., et al. "Effects of an entertainment education radio soap opera on family planning behavior in Tanzania." Studies in family planning 30.3 (1999): 193-211.

75:Vaughan, Peter W., and Everett M. Rogers. "A staged model of communication effects: Evidence from an entertainment-education radio soap opera in Tanzania." Journal of health communication 5.3 (2000): 203-227.

Demographic Projections

76:United Nations World Population Prospects, 27 Billion: the 2010 Revision (above). Raised to 28 Billion in the 2012 Revision. No constant fertility variant in 2015 Revision, but shows increase continuing at a billion/dozen years. link

77:United States Census Bureau, International Data Base

78:Robert J. Wyman (2003) The Projection Problem. Population and Environment 24:329-337.

79:Patrick Gerland & 13 Others (2014) World Population Stabilization unlikely this century. Science 346:234-237.

80:Wolfgang Lutz & 4 others 9 Billion or 11 Billion: The Research Behind New Population Projections.

Unwanted Pregnancy

81:US AID, Demographic and Health Surveys (DHS). DHS, a series since 1984 provides extensive demographic and fertility information from developing countries (preceded by World Fertility Survey, Contraceptive Prevalence Survey, and Knowledge, Attitude and Practice (KAP) Surveys since the 1960s. Inter alia. DHS asks whether recent births were wanted (e.g. Bolivia 2008, only 39% were wanted then) and if woman wanted to stop childbearing (e.g. Bolivia 2008, only 70% wanted no more children).

82:John G. Cleland, Robert P Ndugwa & Eliya M. Zulu (2010) Family Planning in Sub-Saharan Africa: Progress or Stagnation? Bulletin of the World Health Organization. (72% of women in eastern Africa want to postpone or cease childbearing).

83:Bongaarts, John. "The impact of family planning programs on unmet need and demand for contraception." Studies in Family Planning 45.2 (2014): 247-262.

Infant and Child Mortality

84:Jones G, Steketee RW, Black RE, Bhutta ZA, Morris SS, and the Bellagio Child Survival Study Group. How many child deaths can we prevent this year? Lancet 2003; 362:65–71.

85:Maureen Norton: USAID-sponsored estimates suggest that if no births took place within 36 months of a preceding birth, the under-five mortality rate would drop by 35%, and deaths among those younger than age 5 years would fall by 2,875,000 Annually. Office of Population and Reproductive Health, Bureau for Global Health, USAID, Washington, DC 20523, USA (e-mail: mnorton@usaid.gov)

86:Rutstein, Shea. "Effect of birth intervals on mortality and health: multivariate cross-country analysis." Conference on Optimal Birth Spacing for Central America, Antigua, Guatemala. 2003.

Sterilization

87:India: Government of India, National Family Health Survey-4 (2025-2016)

88:India Today, Delhi, Jan 23, 2016 Female Sterilisation is the first choice for family planning in India.

89:US: Deborah Bartz, James A Greenberg 2008 Sterilization in the United States. Rev Obstet Gynecol. 1(1): 23-32. Sterilization is the most common contraceptive method utilized by couples in the United States.

90:Global: United Nations Population Fund. World Contraceptive Patterns 2015.

91: United Nations: Trends in Contraceptive Use Worldwide, 2015

Contraceptive Market and Pricing

92:World Prices; UNICEF: Vaccine Price per dose, Human Papilloma Virus.

93:US Prices: Communicable Disease Control and Prevention, San Francisco Department of Public Health

94:Jack, A. (July 7, 2012) Contraception market expected to reach

95:Contraceptive Research and Development: Looking to the Future. 1996 Institute of Medicine (US) Committee on Contraceptive Research and Development; Harrison PF, Rosenfield A, editors. Washington (DC): National Academies Press (US).

Population and Economic Development

96:Bloom, David E., & Williamson, J. G. (1998). Demographic transitions and economic miracles in emerging Asia. World Bank Economic Review, 12, 419–455

97:Bloom David (2011) 7 Billion and Counting. Science 333:562-568

98:Lee, Ronald and Andrew Mason (2006) What is the Demographic Dividend?

99:International Monetary Fund: Finance and Development 43 (#3):1-5.

Overshoot

100:Meadows, Donella, Jorgen Randers, and Dennis Meadows. Limits to growth: The 30-year update. Chelsea Green Publishing, 2004.

101:Wackernagel, Mathis, and William Rees. Our ecological footprint: reducing human impact on the earth. No. 9. New Society Publishers, 1998.

102:Wackernagel, Mathis, et al. "Tracking the ecological overshoot of the human economy." Proceedings of the national Academy of Sciences 99.14 (2002): 9266-9271.

103:Tainter, Joseph A. "Archaeology of overshoot and collapse." Annu. Rev. Anthropol. 35 (2006): 59-74.

104:Coole, Diana. "Too many bodies? The return and disavowal of the population question." Environmental Politics 22.2 (2013): 195-215.

105:Von Foerster, Heinz, Patricia M. Mora, and Lawrence W. Amiot. "Doomsday: Friday, 13 november, ad 2026." Science 132.3436 (1960): 1291-1295.

106:Ehrlich, Paul R., and Anne H. Ehrlich. "The population explosion. Why isnt everyone as scared as we are?." AMICUS JOURNAL 12.1 (1990): 22-9.

107:Toth, Gergely, and Cecília Szigeti. "The historical ecological footprint: From over-population to over-consumption." Ecological Indicators 60 (2016): 283-291.

108:Ott, Jan. "Less Happiness in Cities, but Why and so What? One More Reason to Stop Overpopulation." Journal of Happiness Studies (2016): 1-6.

109:Mendenhall, CD, GC Daily and PR Ehrlich. 2012. Improving estimates of biodiversity loss. Biological Conservation 151: 32-34.