Protein Structure Determination, Fall 2017

Meets Mon/Thurs 10-11:50 in J-Rowl 2C13
Office hours Fridays 10-12 J-Rowl 3C07

Syllabus for 2017


Lectures

√∅ Slides Title     When Reading Due
Lecture 1 Overview: crystals and symmetry  PDF  Thu, Aug 31      
Lecture 2 The scattering of X-rays by electrons.  PDF  Thu, Sep 7  Ch 3, 5, 6.2  Ex 1  
Lecture 3 Bragg’s law. Diffraction.  PDF  Mon, Sep 11  Ch 4, 7.5.3  Ex 2  
Lecture 4 The Reciprocal lattice.  PDF  Thu, Sep 14  Ch 6.3-6.3.2  HW1  
Lecture 5 Phasing. Molecular replacement.  PDF  Mon, Sep 18  Ch 6.3.3, 6.4  Ex 3  
Lecture 6 Molecular replacement. Heavy Atoms.  PDF  Thu, Sep 21  Ch. 6.5-7.4  Ex 4  
Lecture 7 Anomalous dispersion. Refinement.  PDF  Mon, Sep 25  Ch 7.5-8.2  Ex 5  
Lecture 8 Refinement. B-factors  PDF  Thu, Sep 28  Coot, CCP4  HW2  
Lecture 9 Model building. Phenix.  PDF  Mon,Oct 2  Ch 7.7, 8.3  Ex 6  
Lecture 10 Model validation.  PDF  Thu, Oct 5    Ex 7  
Lecture 11 Comparing proteins.  PDF  Tue, Oct 10    Ex 8  
Lecture 12 Laue photography and MicroED  PDF  Thu,Oct 12    HW3  
Lecture 13 review session  PDF  Mon, Oct 16      
Lecture 14 MIDTERM (Xray)  PDF  Thu, Oct 19      
Go to Prof Wang's course page

Links etc

 Syllabus   Unix stuff  Download Jmol Download XrayView Download CCP4
 JQquestion   Bragg Planes (java)   Homework 4 
 Homework 5   Term Project   Get a PDB file   Homework 6   Homework X 
 short course 1   short course 2   MolProbity   Escher web sketch 
 Coot tutorial   Full Xray data set (716 Mb zip file) 
 Fobs map   Unrefined coordinates   Spacegroup images  Crystal math 
 COOT tutorial PDB file   COOT tutorial MTZ file   Ex 8 paper 
 PDB for Phenix  MTZ for Phenix  SEQ for Phenix
 4m6k  7dfr

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Last updated Tue Oct 10 00:00:41 EDT 2017 Mon Oct 9 21:46:51 EDT 2017 W3C validation