I-sites Libraries 2008

I-sites is a method for predicting the local structure of a protein. Local structure can be expressed as fragments or as backbone angles. Locations in the protein sequence that have high confidence I-sites predictions may be the initiation sites of folding.

I-sites consists of about 250 motifs. Each motif has an amino acid profile, a fragment structure (represented by a "paradigm" fragment chosen from a protein in the PDB) and optionally, a 4-dimensional tensor of pairwise sequence covariance. Each of the links below points you to a different version of the library, with brief notes about how the library was created and how it differs from the other libraries.

This site is for inspecting and downloading the I-sites Libraries. For prediction using I-sites, please go to this server.

Current I-sites Libraries

3.1

5.1

5.2

5.3

I-sites source

covar.tgz